Nicolas CAGNARD | Institut Imagine

Presentation

Nicolas CAGNARD

Bioinformatics

Contact :

01 42 75 44 78

nicolas.cagnard@institutimagine.org

About

Scientific Publications

Publications

2026

STAG2 mutations fine-tune the ALK-driven oncogenic program in ALK-positive an..., Blood
2026

Nuclear class 3 PI3K co-activates fasting-specific chromatin remodelling., Nat Cell Biol
2026

Cilia to basement membrane signaling is a biomechanical driver in models of a..., American Society for Clinical Investigation
2026

Developmental switch dichotomizes kidney response to NPHP3 inactivation and t..., openRxiv
2026

A cilia-dependent inflammatory programme links bacterial detection to kidney ..., openRxiv
2026

No Correlation Between Interferon Signaling and Cytosolic Mitochondrial DNA/R..., Eur J Immunol
2025

AXL mediates mast cell survival and resistance to tyrosine kinase inhibitors ..., openRxiv
2025

Kinesin-1 coordinates cross-talk between microtubule and actin cytoskeletons ..., Sci Adv
2025

Prostaglandin Analogs and Eupatilin as Treatments for Nephronophthisis., Kidney Int Rep
2025

Metallophilic marginal zone macrophages cross-prime CD8 T cell-mediated prote..., Immunity
2025

Autoinflammatory encephalopathy due to PTPN1 haploinsufficiency: a case series., Lancet Neurol
2025

Author Correction: Mutations in ACTRT1 and its enhancer RNA elements lead to ..., Nat Med
2025

Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and i..., J Exp Med
2024

Overexpression of Egr1 Transcription Regulator Contributes to Schwann Cell Di..., Cells
2024

Congenital microcoria deletion in mouse links Sox21 dysregulation to disease ..., Am J Hum Genet
2024

Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from E..., J Exp Med
2024

Targeted RNAseq from patients' urinary cells to validate pathogenic noncoding..., Kidney Int
2024

Compound heterozygous mutations in the kinase domain of IKKα lead to immunode..., medRxiv
2023

FLT3L-dependent dendritic cells control tumor immunity by modulating Treg and..., Cell Rep Med
2023

Borealin/CDCA8 deficiency alters thyroid development and results in papillary..., Front Endocrinol (Lausanne)
2023

Fluid shear stress triggers cholesterol biosynthesis and uptake in inner medu..., Front Mol Biosci
2023

Cell Plasticity in a Mouse Model of Benign Prostate Hyperplasia Drives Amplif..., Am J Pathol
2023

PRIMA-1/APR-246 Can Partially Rescue In Vitro Cell Adhesion of Patient-Derive..., J Invest Dermatol
2023

A wave of deep intronic mutations in X-linked Alport syndrome., Kidney Int
2023

Hydroxychloroquine sulfate: A novel treatment for lipin-1 deficiency?, Biomed Pharmacother
2023

Modulation of Monocyte Response by MicroRNA-15b/106a/374a During Antibody-med..., Transplantation
2023

A shared pattern of altered gene expression in human embryos affected by mito..., Hum Reprod
2022

Neuropilin-1 cooperates with PD-1 in CD8 T cells predicting outcomes in melan..., iScience
2022

Agonists of prostaglandin E receptors as potential first in class treatment f..., Proc Natl Acad Sci U S A
2022

Class 3 phosphoinositide 3-kinase promotes hepatic glucocorticoid receptor st..., Acta Physiol (Oxf)
2021

A monocyte/dendritic cell molecular signature of SARS-CoV-2-related multisyst..., Med
2021

The alternative RelB NF-κB subunit is a novel critical player in diffuse larg..., Blood
2021

A DL-4- and TNFα-based culture system to generate high numbers of nonmodified..., Cell Mol Immunol
2021

Bi-allelic variants in IPO8 cause a connective tissue disorder associated wit..., Am J Hum Genet
2021

Disruption of pathways regulated by Integrator complex in Galloway-Mowat synd..., Sci Rep
2020

Mobilized Multipotent Hematopoietic Progenitors Stabilize and Expand Regulato..., Front Immunol
2020

Unique inflammatory signature in haemophilic arthropathy: miRNA changes due t..., J Cell Mol Med
2020

Tumor invasion in draining lymph nodes is associated with Treg accumulation i..., Nat Commun
2020

IL-15 superagonist RLI has potent immunostimulatory properties on NK cells: i..., J Immunother Cancer
2020

MeCP2 is involved in random mono-allelic expression for a subset of human aut..., Biochim Biophys Acta Mol Basis Dis
2020

Clonal tracking in gene therapy patients reveals a diversity of human hematop..., Blood
2020

CBFβ-SMMHC Affects Genome-wide Polycomb Repressive Complex 1 Activity in Acut..., Cell Rep
2019

A variant erythroferrone disrupts iron homeostasis in -mutated myelodysplasti..., Sci Transl Med
2019

Ttc7a regulates hematopoietic stem cell functions while controlling the stres..., Haematologica
2019

The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by ..., Nat Commun
2019

Early Acute Microvascular Kidney Transplant Rejection in the Absence of Anti-..., J Am Soc Nephrol
2018

Tetratricopeptide repeat domain 7A is a nuclear factor that modulates transcr..., Cell Discov
2018

Role of in neural stem cell differentiation and neural lineage determination..., Mol Autism
2018

Periosteum contains skeletal stem cells with high bone regenerative potential..., Nat Commun
2018

Acellular therapeutic approach for heart failure: in vitro production of extr..., Eur Heart J
2018

BAFF and CD4 T cells are major survival factors for long-lived splenic plasma..., Blood
2017

Type I interferon-mediated autoinflammation due to DNase II deficiency., Nat Commun
2017

Generation of adult human T-cell progenitors for immunotherapeutic applications., J Allergy Clin Immunol
2017

UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-p..., Nat Commun
2017

Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation..., Nat Med
2017

Klhl6 Deficiency Impairs Transitional B Cell Survival and Differentiation., J Immunol
2017

A rare castration-resistant progenitor cell population is highly enriched in ..., J Pathol
2017

Atorvastatin reduces β-Adrenergic dysfunction in rats with diabetic cardiomyo..., PLoS One
2016

Early born neurons are abnormally positioned in the doublecortin knockout hip..., Hum Mol Genet
2016

Homogeneous Inflammatory Gene Profiles Induced in Human Dermal Fibroblasts in..., PLoS One
2016

Interleukin-15-Dependent T-Cell-like Innate Intraepithelial Lymphocytes Devel..., Immunity
2016

Regulatory T cells delay disease progression in Alzheimer-like pathology., Brain
2016

Variability of response to methadone: genome-wide DNA methylation analysis in..., Epigenomics
2015

Mutations in NONO lead to syndromic intellectual disability and inhibitory sy..., Nat Neurosci
2015

TCL1 expression patterns in Waldenström macroglobulinemia., Mod Pathol
2015

AK2 deficiency compromises the mitochondrial energy metabolism required for d..., Cell Death Dis
2015

Two persistent organic pollutants which act through different xenosensors (al..., Biochimie
2015

Emergence of long-lived autoreactive plasma cells in the spleen of primary wa..., J Autoimmun
2015

Synergy of chemotherapy and immunotherapy revealed by a genome-scale analysis..., J Antimicrob Chemother
2015

Heterogeneous CD3 expression levels in differing T cell subsets correlate wit..., J Immunol
2014

Metabolic and adipose tissue signatures in adults with Prader-Willi syndrome:..., J Clin Endocrinol Metab
2014

Reverse interferon signature is characteristic of antigen-presenting cells in..., Arthritis Rheumatol
2014

Identification of a human splenic marginal zone B cell precursor with NOTCH2-..., J Exp Med
2013

Limitations of IL-2 and rapamycin in immunotherapy of type 1 diabetes., Diabetes
2013

Genotoxic signature in cord blood cells of newborns exposed in utero to a Zid..., J Infect Dis
2013

Lung tumor microenvironment induces specific gene expression signature in int..., Front Immunol
2012

B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma..., J Clin Invest
2012

Translation termination efficiency modulates ATF4 response by regulating ATF4..., Nucleic Acids Res
2012

Functional intestinal stem cells after Paneth cell ablation induced by the lo..., Proc Natl Acad Sci U S A
2012

Angiotensin II facilitates breast cancer cell migration and metastasis., PLoS One
2012

A lineage of myeloid cells independent of Myb and hematopoietic stem cells., Science
2012

Combined loss of cRel/p50 subunits of NF-κB leads to impaired innate host res..., Innate Immun
2012

Srf-dependent paracrine signals produced by myofibers control satellite cell-..., Cell Metab
2011

Identification of molecular pathways involved in oxaliplatin-associated sinus..., J Hepatol
2011

Implication of clusterin in TNF-α response of rheumatoid synovitis: lesson fr..., Physiol Genomics
2011

Combined transcriptomic-(1)H NMR metabonomic study reveals that monoethylhexy..., J Proteome Res
2011

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on S..., Dev Biol
2011

Insights into the pathogenesis of systemic sclerosis based on the gene expres..., Arthritis Rheum
2011

Nuclear outsourcing of RNA interference components to human mitochondria., PLoS One
2011

KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes., Nat Genet
2011

Systematic candidate gene investigations in the SPA2 locus (9q32) show an ass..., Arthritis Rheum
2010

The transforming growth factor-α and cyclin D1 genes are direct targets of β-..., J Hepatol
2010

Cell cloning-based transcriptome analysis in cyclin-dependent kinase-like 5 m..., J Mol Med (Berl)
2010

Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 a..., Immunity
2010

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pa..., J Exp Med
2010

Gene expression profile in the salivary glands of primary Sjögren's syndrome ..., Arthritis Rheum
2009

Comprehensive linkage and association analyses identify haplotype, near to th..., PLoS Genet
2009

The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces..., J Clin Invest
2009

Gene expression profiling provides insights into the pathways involved in sol..., J Pathol
2008

FOXO1 regulates L-Selectin and a network of human T cell homing molecules dow..., J Immunol
2006

Failure to confirm coxsackievirus infection in primary Sjögren's syndrome., Arthritis Rheum
2006

Activation of IFN pathways and plasmacytoid dendritic cell recruitment in tar..., Proc Natl Acad Sci U S A
2006

Interleukin-32, CCL2, PF4F1 and GFD10 are the only cytokine/chemokine genes d..., Eur Cytokine Netw
2004

DNA microarray allows molecular profiling of rheumatoid arthritis and identif..., Genes Immun

Presentation

About

Scientific Publications

STAG2 mutations fine-tune the ALK-driven oncogenic program in ALK-positive an..., Blood

Nuclear class 3 PI3K co-activates fasting-specific chromatin remodelling., Nat Cell Biol

Cilia to basement membrane signaling is a biomechanical driver in models of a..., American Society for Clinical Investigation

Developmental switch dichotomizes kidney response to NPHP3 inactivation and t..., openRxiv

A cilia-dependent inflammatory programme links bacterial detection to kidney ..., openRxiv

No Correlation Between Interferon Signaling and Cytosolic Mitochondrial DNA/R..., Eur J Immunol

AXL mediates mast cell survival and resistance to tyrosine kinase inhibitors ..., openRxiv

Kinesin-1 coordinates cross-talk between microtubule and actin cytoskeletons ..., Sci Adv

Prostaglandin Analogs and Eupatilin as Treatments for Nephronophthisis., Kidney Int Rep

Metallophilic marginal zone macrophages cross-prime CD8 T cell-mediated prote..., Immunity

Autoinflammatory encephalopathy due to PTPN1 haploinsufficiency: a case series., Lancet Neurol

Author Correction: Mutations in ACTRT1 and its enhancer RNA elements lead to ..., Nat Med

Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and i..., J Exp Med

Overexpression of Egr1 Transcription Regulator Contributes to Schwann Cell Di..., Cells

Congenital microcoria deletion in mouse links Sox21 dysregulation to disease ..., Am J Hum Genet

Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from E..., J Exp Med

Targeted RNAseq from patients' urinary cells to validate pathogenic noncoding..., Kidney Int

Compound heterozygous mutations in the kinase domain of IKKα lead to immunode..., medRxiv

FLT3L-dependent dendritic cells control tumor immunity by modulating Treg and..., Cell Rep Med

Borealin/CDCA8 deficiency alters thyroid development and results in papillary..., Front Endocrinol (Lausanne)

Fluid shear stress triggers cholesterol biosynthesis and uptake in inner medu..., Front Mol Biosci

Cell Plasticity in a Mouse Model of Benign Prostate Hyperplasia Drives Amplif..., Am J Pathol

PRIMA-1/APR-246 Can Partially Rescue In Vitro Cell Adhesion of Patient-Derive..., J Invest Dermatol

A wave of deep intronic mutations in X-linked Alport syndrome., Kidney Int

Hydroxychloroquine sulfate: A novel treatment for lipin-1 deficiency?, Biomed Pharmacother

Modulation of Monocyte Response by MicroRNA-15b/106a/374a During Antibody-med..., Transplantation

A shared pattern of altered gene expression in human embryos affected by mito..., Hum Reprod

Neuropilin-1 cooperates with PD-1 in CD8 T cells predicting outcomes in melan..., iScience

Agonists of prostaglandin E receptors as potential first in class treatment f..., Proc Natl Acad Sci U S A

Class 3 phosphoinositide 3-kinase promotes hepatic glucocorticoid receptor st..., Acta Physiol (Oxf)

A monocyte/dendritic cell molecular signature of SARS-CoV-2-related multisyst..., Med

The alternative RelB NF-κB subunit is a novel critical player in diffuse larg..., Blood

A DL-4- and TNFα-based culture system to generate high numbers of nonmodified..., Cell Mol Immunol

Bi-allelic variants in IPO8 cause a connective tissue disorder associated wit..., Am J Hum Genet

Disruption of pathways regulated by Integrator complex in Galloway-Mowat synd..., Sci Rep

Mobilized Multipotent Hematopoietic Progenitors Stabilize and Expand Regulato..., Front Immunol

Unique inflammatory signature in haemophilic arthropathy: miRNA changes due t..., J Cell Mol Med

Tumor invasion in draining lymph nodes is associated with Treg accumulation i..., Nat Commun

IL-15 superagonist RLI has potent immunostimulatory properties on NK cells: i..., J Immunother Cancer

MeCP2 is involved in random mono-allelic expression for a subset of human aut..., Biochim Biophys Acta Mol Basis Dis

Clonal tracking in gene therapy patients reveals a diversity of human hematop..., Blood

CBFβ-SMMHC Affects Genome-wide Polycomb Repressive Complex 1 Activity in Acut..., Cell Rep

A variant erythroferrone disrupts iron homeostasis in -mutated myelodysplasti..., Sci Transl Med

Ttc7a regulates hematopoietic stem cell functions while controlling the stres..., Haematologica

The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by ..., Nat Commun

Early Acute Microvascular Kidney Transplant Rejection in the Absence of Anti-..., J Am Soc Nephrol

Tetratricopeptide repeat domain 7A is a nuclear factor that modulates transcr..., Cell Discov

Role of in neural stem cell differentiation and neural lineage determination..., Mol Autism

Periosteum contains skeletal stem cells with high bone regenerative potential..., Nat Commun

Acellular therapeutic approach for heart failure: in vitro production of extr..., Eur Heart J

BAFF and CD4 T cells are major survival factors for long-lived splenic plasma..., Blood

Type I interferon-mediated autoinflammation due to DNase II deficiency., Nat Commun

Generation of adult human T-cell progenitors for immunotherapeutic applications., J Allergy Clin Immunol

UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-p..., Nat Commun

Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation..., Nat Med

Klhl6 Deficiency Impairs Transitional B Cell Survival and Differentiation., J Immunol

A rare castration-resistant progenitor cell population is highly enriched in ..., J Pathol

Atorvastatin reduces β-Adrenergic dysfunction in rats with diabetic cardiomyo..., PLoS One

Early born neurons are abnormally positioned in the doublecortin knockout hip..., Hum Mol Genet

Homogeneous Inflammatory Gene Profiles Induced in Human Dermal Fibroblasts in..., PLoS One

Interleukin-15-Dependent T-Cell-like Innate Intraepithelial Lymphocytes Devel..., Immunity

Regulatory T cells delay disease progression in Alzheimer-like pathology., Brain

Variability of response to methadone: genome-wide DNA methylation analysis in..., Epigenomics

Mutations in NONO lead to syndromic intellectual disability and inhibitory sy..., Nat Neurosci

TCL1 expression patterns in Waldenström macroglobulinemia., Mod Pathol

AK2 deficiency compromises the mitochondrial energy metabolism required for d..., Cell Death Dis

Two persistent organic pollutants which act through different xenosensors (al..., Biochimie

Emergence of long-lived autoreactive plasma cells in the spleen of primary wa..., J Autoimmun

Synergy of chemotherapy and immunotherapy revealed by a genome-scale analysis..., J Antimicrob Chemother

Heterogeneous CD3 expression levels in differing T cell subsets correlate wit..., J Immunol

Metabolic and adipose tissue signatures in adults with Prader-Willi syndrome:..., J Clin Endocrinol Metab

Reverse interferon signature is characteristic of antigen-presenting cells in..., Arthritis Rheumatol

Identification of a human splenic marginal zone B cell precursor with NOTCH2-..., J Exp Med

Limitations of IL-2 and rapamycin in immunotherapy of type 1 diabetes., Diabetes

Genotoxic signature in cord blood cells of newborns exposed in utero to a Zid..., J Infect Dis

Lung tumor microenvironment induces specific gene expression signature in int..., Front Immunol

B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma..., J Clin Invest